Amazing Spider-Man Wiki

Cross-Species Hybrids are genetically altered humans that have taken on the characteristics of certain animal species to some extent. These creatures have extremely enhanced abilities that normal humans do not possess, and as such have several unique powers, strengths and weaknesses.


Curt Connors, a scientist at Oscorp, developed a serum replicating the self-healing processes of lizards with the intent of regaining his lost right arm. However, while he regained his arm, the serum had several side-effects causing him to transform into a mutant lizard. While in Lizard form, he believed that he had achieved the next stage of human evolution and attempted to release his serum throughout New York City in order to transform everyone into humanoid lizards. However, he was stopped, defeated and ultimately cured by Peter Parker, who had become Spider-Man.

Notable cross-species[]

  • Peter Parker (Spider-Man, controllable, halfly turned)
  • Curt Connors (Lizard, briefly controllable, fully turned, cured)
  • Edward Whelan (Vermin, fully turned; video game)
  • Iguana (fully turned; video game)
  • Scorpion (fully turned; video game)
  • Infected (briefly controllable, halfly turned; video game)
  • Aleksei Sytsevich (Rhino, fully turned)
  • Alistaire Smythe (controllable, halfly turned, deceased; video game)
  • Gwen Stacy (controllable, halfly turned, cured; video game)
  • Max Dillon (possibly)
  • Harry Osborn (possibly)
  • New York Civillians (controllable, halfly turned, cured)