- “I was the one who wiped your nose and made you brush your teeth and do your homework and washed your dirty underwear. Me! Your stupid, non-scientific aunt, who doesn't know how to make ends meet, who has to take nursing classes with twenty-two year old kids so I can pay for you to go to college. And I don't know how to do this without Ben! I don't know how! And...and you're dreaming about your perfect father, who was never here. No! No, I won't tell you. You're my boy. As far as I'm concerned, you're my boy, and I won't hurt you.”
- ―Aunt May[src]
Originally a very naive girl in her youth, she eventually discovered her affections for her schoolmate Ben Parker and married him.
Little did they know at the time, Peter's presence with the two would strengthen their relationship. May and Ben would act as parents to Peter. They lived normally until Peter gained powers, these powers would lead him to become the masked hero Spider-Man, but, because of this, Peter would come home late at night, often to his aunt and uncle's questioning toward this.
One night when Peter came home late, Ben had been fed up with him always being late, he demanded that Peter apologize to his aunt, only for Peter to storm out of the house, slamming and breaking the glass in the door. Ben went out to look for him, only to be confronted by a man with a gun, who was running from the police. Ben tried to stop the man, but, was shot in the stomach. May was heartbroken.
Though Peter did not tell her where he went or where he would go during this time, she lived with the mystery and continued to love him.
Later when a Large Lizard creature attacked New York May was beside the TV watching the events play out. When the threat was stopped Peter returned home with scratches and bruises, but he also returned with the eggs she had asked for earlier on. The two embraced with May comforting her hurting nephew. The next day when Gwen Stacy came by, Peter asked her why he didn't ask her out, Peter told her it was because he was no good for her, but May assured him he was.
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