A list of trivia from The Amazing Spider-Man 2.
- In August 2011, eleven months before the release of The Amazing Spider-Man (2012), Sony announced the release date for this sequel.
- When asked the relationship between Peter and Gwen, Emma Stone told Total Film that: "She [Gwen] saves him [Peter] more than he saves her. She's incredibly helpful to Spider-Man... He's the muscle, she's the brains."
- The final battle between the Green Goblin (Dane DeHaan) and Spider-Man (Andrew Garfield) was filmed in an actual clock tower where temperatures would reach 115 degrees. DeHaan had to wear 3 1/2 hours worth of prosthetics and make up, as well as his goblin costume, which weighed 50 lbs and couldn't be opened without power tools. After DeHaan lost 7 lbs in a single day, the film's medic was so concerned that DeHaan would get heat stroke, that crew members were told to pour buckets of ice on DeHaan's head and down his suit between takes. Unfortunately, this didn't work because his body temperature was so high that the ice would melt and turn into steam before he could feel the effects of the ice. Eventually, a tubing system that would pump cold water was installed in the goblin suit so that the cooler temperatures could reach DeHaan's body.
- The dog that Gwen walks while Peter spies on her from a rooftop, actually belongs to Andrew Garfield and Emma Stone. They adopted him in 2013.
- This is the first "Spider-Man" film to be filmed entirely in New York, and the largest film production ever in New York City.
- The film's mid-credits scene teases X-Men: Days of Future Past, produced by 20th Century Fox, while The Amazing Spider-Man 2 is produced by Sony/Columbia Pictures. This is because the director Marc Webb has a contract with Fox to make another film for them after the first Amazing Spider-Man movie, but instead of doing so, he signed to do this movie. This was allowed by Fox if Sony would agree to promote their next X-Men movie for free.
- The film's portrayal of the Rhino combines aspects from the comics of the Rhino from the mainstream universe (the Rhino's real name Aleksei Sytsevich and background) and Ultimate universe (where instead of gaining superpowers or wearing a normal suit, he pilots a Rhino-themed exo suit similar to Iron Man).
- The Green Goblin in the film is a combination of the mainstream (glider and armor) and the Ultimate (mutated).
- During the scene where Peter and Gwen see each other for the first time in a year, Andrew Garfield's heel was run over by a taxi.
- Two display cases in Oscorp feature a set of metal wings, and an exoskeleton holding four arms. These are homages to Spider-Man's antagonists the Vulture (Adrian Toomes) and Doctor Octopus (Otto Octavius).
- Three Spider-Man villains have minor roles in the movie. A female Oscorp employee named Felicia Hardy, who is also known as Black Cat, a cat burglar and occasionally a love interest of Spider-Man. Alistair Smythe also makes a brief appearance. In the comics, he builds the Spider Slayers, robots built to hunt Spider-Man, and eventually becomes the Spider Slayer. Aleksei Sytsevich makes a minor appearance as the Rhino at the end of the movie.
- Early on in the film, Max Dillon has a birthday cake in his fridge that is white with green icing and yellow lightning bolts. This is an homage to the original Electro suit from the comics.
- Jamie Foxx and Chris Cooper are the first Oscar winners to portray Spider-Man villains.
- Several lines featured in the trailers do not appear in the film, including Peter saying "You know what I love about being Spider-Man? Everything." and Harry telling Peter "Oscorp has got you under surveillance."
- At 142 minutes, this is the longest Spider-Man film as of its release.
- Chris Cooper (who plays Norman Osborn in this second film of the Marc Webb series) was considered for the role of Doc Ock/Dr. Otto Octavius in the second film of the Sam Raimi series.